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Lars Björndahl (cv)
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Lars Björndahl established LB Andrologikonsult in 1995 primarily to support the Andrology Laboratory at the Karolinska University Hospital, Solna, Sweden. I have been part of the development of this unit from the early beginning in the late 1980:ies including the process of accreditation by the Swedish accreditation authority, Swedac, in 2007.

Among Commissions

Project leader for national investigations concerning postmortal viral testing as a part of tne National Tissue Project,

Development of quality manuals, checklists and other materials for the Swedish National Tissueproject (implementation of EG directives on Cells and Tissues).

Consultancy for the establishment of an andrology laboratory, University of Dundee, Scotland. Course in Basic Semen Analysis in Birmingham, UK.

Quality Control and Assessment, teaching and training, Andrology Unit at the Karolinska University Hospital, Stockholm, Sweden.

Curriculum vitae

Education

  • Specialist in clinical chemistry 1992
  • Licensed physician in 1990
  • Ph D, Department of Physiology, Karolinska Institutet, 1982-1986
  • MD, Karolinska Institutet 1976-1982

Work as scientist/physician

  • Senior Consultant Physicain in Andrology, Centre for Andrology and Sexual Medicine, Clinic for Endocrinology, Department of Medicine, Karolinska University Hospital, since May 2010.
  • Advisor in laboratory andrology, part time 1995-2007, full time since 2007
  • Director of Andrology, Assisted Conception Unit, Birmingham Women's Hospital, Birmingham, UK; 2004-2005.
  • Scientist in Reproductive Biology (Assisted Conception Unit, Birmingham Women's Hospital, Birmingham, UK; 2002-2004)
  • Research Fellow and Honorary Senior Lecturer in Reproductive Biology (University of Birmingham, UK, 2001-2005)
  • Ward physician, Andrology Laboratory (Reproductive Medicine Centre, Karolinska University Hospital, Solna; 1993-1998)
  • Clinical Chemistry: intern physician 1990-1993
  • Intern physician (medicine, surgery, anaesthetics, ortopedics, psychiatry, district health service; Köpings Lasarett (1980), Sabbatsbergs hospital (1987-89), Beckomberga hospital (1989), Lidingö hospital (1981-84) and Bergshamra Vårdcentral, Solna (1990)
  • Assistant teacher, junior research fellow and substituting senior university lecturer (Dept of Physiology, Karolinska Institutet, 1979-1990)

Among scientific commissions

  • Member of Editorial Board, Andrology (2013-)
  • Member of Editorial Board, Asian Journal of Andrology (2011)
  • Member of Editorial Board, Journal of Andrology (2010-2012)
  • Associate Editor, Human Reproduction (2010-)
  • Member of Steering Group for the Karolinska Network for Reproduction, Growth and Development (2009-)
  • Science Secretary of the Swedish Society of Andrology (2009-)
  • President in NAFA (2007-)
  • Co-ordinator of the ESHRE Special Interest Group in Andrology (2004-2008)
  • Member of the editorial committee for the fifth edition of the WHO manual on semen analysis (2005-2007)
  • Sekretary in the NAFA Workgroup for semen analysis techniques (1995-2002)

Ph.D. students

  • Emma Holmes
  • Emelie Ekwurtzel

Scientific publications

A] Published original work

2013 Mortimer, D., Barratt, C. L. R., Björndahl, L., de Jager, C., Jequier, A. M. and Muller, C. H. (2013) What should it take to describe a substance or product as ‘sperm-safe’. Hum Reprod Update, 19, i1-i45.
2012 Sánchez-Pozo MC, Mendiola J, Serrano M, Mozas J, Björndahl L, Menkveld R, Lewis SE, Mortimer D, Jørgensen N, Barratt CL, Fernández MF, Castilla JA; Special Interest Group in Andrology of the European Society of Human Reproduction and Embryology. Proposal of guidelines for the appraisal of SEMen QUAlity studies (SEMQUA). Human Reproduction. 28 (1) 10-21
2011 Palacios, E. R., Clavero, A., Gonzalvo, M. C., Rosales, A., Mozas, J., Martinez, L., Ramirez, J. P., Björndahl, L., Morancho-Zaragoza, J., Fernandez-Pardo, E. et al. Acceptable variability in external quality assessment programmes for basic semen analysis. Human reproduction (Oxford, England). 27(2):314-22.
2009 Kirkman-Brown J and Björndahl L. Evaluation of a disposable plastic Neubauer counting chamber for semen analysis. Fertil Steril, 91(2): 627-31.
2006 Björndahl L., Kirkman-Brown J., Hart G., Rattle S. and Barratt C.L. Development of a novel home sperm test. Hum Reprod; 21(1): 145-9.
2005 Bjorndahl L., Mohammadieh M., Pourian M., Söderlund I. and Kvist U. Contamination by seminal plasma factors during sperm selection. J Androl; 26(2): 170-3.
2005 Moseley F.L., Jha K.N., Björndahl L., Brewis I.A., Publicover S.J., Barratt C.L. and Lefievre L. Protein tyrosine phosphorylation, hyperactivation and progesterone-induced acrosome reaction are enhanced in IVF media: an effect that is not associated with an increase in protein kinase A activation. Mol Hum Reprod; 11(7): 523-9
2004 Pixton, Deeks, Flesch, Moseley, Björndahl, Ashton, Barratt & Brewis. Sperm proteome mapping of a patient who experienced failed fertilization at IVF reveals altered expression of at least twenty proteins compared to fertile donors: case report. Hum Reprod. 19(6):1438-47.
2004 Björndahl, Söderlund, Johansson, Mohammadieh, Pourian, Kvist U. Why the WHO recommendations for eosin-nigrosin staining techniques for human sperm vitality assessment must change. J Androl. 25(5):671-8.
2003 Björndahl, Söderlund & Kvist. Evaluation of the one-step eosin-nigrosin staining technique for human sperm vitality assessment. Hum Reprod 18(4):813-816.
2003 Ola, Afnan, Papaioannou, Sharif, Björndahl & Coomarasamy. Accuracy of sperm-cervical mucus penetration tests in evaluating sperm motility in semen: a systematic quantitative review. Human Reprod 18(5):1037-1046.
2002 Björndahl, Barratt, Fraser, Kvist & Mortimer. ESHRE basic semen analysis courses 1995-1999: immediate beneficial effects of standardized training. Hum Reprod, 17: 1399-1405.
2002 Kvist & Björndahl. Editorial for Manual on Basic Semen Analysis, ESHRE Monographs, Oxford University Press, Oxford
2002 Cooper, Björndahl, Vreeburg & Nieschlag. Semen analysis and external quality control schemes for semen analysis need global standardisation. Int J Androl, 25(5):306-311
1995 Pourian, Kvist, Björndahl & Oliw. Rapid and Slow Hydroxylators of Seminal E Prostaglandins among Men in Barren Unions. Andrologia, 27: 71-79.
1992 Kjellberg, Björndahl & Kvist. Sperm chromatin stability and zinc binding properties in semen from men in barren unions. Int J Androl, 15:103-113.
1991 Björndahl, Kjellberg & Kvist, Ejaculatory sequence in men with low sperm chromatin zinc, Int J Androl, 14: 174-178.
1990 Björndahl & Kvist, Influence of seminal vesicular fluid on content of zinc in human sperm chromatin, Int J Androl, 13: 232-237.
1990 Kvist, Kjellberg, Björndahl, Soufir & Arver, Seminal fluid from men with agenesis of the Wolffian ducts: zinc binding properties and effects on sperm chromatin stability, Int J Androl, 13: 245-252
1990 Rosenborg, Rao, Björndahl, Kvist, Pousette, Åkerlöf & Fredricsson, Changes in human sperm chromatin stability during preparation for in vitro fertilization, Int J Androl, 13: 287-296.
1988 Kvist, Kjellberg, Björndahl, Hammar & Roomans, Zinc in sperm chromatin and chro­matin stability in fertile men and men in barren unions, Scand J Urol Nephrol 22: 1-6.
1987 Casswall, Björndahl & Kvist, Cadmium interacts with a zinc-dependent stability of the human sperm chromatin, Trace Elem Electrol Health Disease 1: 85-87.
1987 Kvist, Björndahl & Kjellberg, Sperm nuclear zinc, chromatin stability and male fertility, Scanning Microscopy 1: 1241-1247.
1986 Björndahl, Kjellberg, Roomans & Kvist, The human sperm nucleus takes up zinc at ejaculation, Int J Androl 9: 77-80.
1985 Björndahl & Kvist, Loss of an intrinsic capacity for human sperm chromatin decondensation, Acta Physiol Scand 124: 189-194.
1985 Kvist & Björndahl, Zinc preserves an inherent capacity for human sperm chromatin decondensation, Acta Physiol Scand 124: 195-200.
1985 Kvist, Björndahl, Roomans & Lindholmer, Nuclear zinc in human epididymal and ejaculated spermatozoa, Acta Physiol Scand 125: 297-303.
1982 Björndahl & Kvist, Importance of zinc for human sperm head-tail connection, Acta Physiol Scand 116: 51-55.
1982 Roomans, Lundevall, Björndahl & Kvist, Removal of zinc from subcellular regions of ejaculated human spermatozoa by EDTA treatment studied by X-ray microanalysis, Int J Androl 5: 478-486.

B] Reviews and commentaries

2013 Mortimer D, Barratt CLR, Björndahl L, de Jager C, Jequier JM and Muller C. What Should It Take To Describe a Substance or Product as “Sperm-Safe”. Human Reproduction Update, in press.
2013 Björndahl L. Methods for sperm concentration determination. Methods Mol Biol; 927:3-12
2011 Barratt, C. L., Bjorndahl, L., Menkveld, R. and Mortimer, D. ESHRE special interest group for andrology basic semen analysis course: a continued focus on accuracy, quality, efficiency and clinical relevance. Human reproduction (Oxford, England), 26, 3207-3212.
2011 Björndahl, L. and Kvist, U. A model for the importance of zinc in the dynamics of human sperm chromatin stabilization after ejaculation in relation to sperm DNA vulnerability. Syst Biol Reprod Med, 57, 86-92.
2011 Björndahl, L. (2011) What is normal semen quality? On the use and abuse of reference limits for the interpretation of semen analysis results. Human fertility (Cambridge, England), 14, 179-186.
2010 Barratt CLR, Aitken RJ, Björndahl L, Carrell D, de Boer P, Kvist U, Lewis SEM, Perreault SD, Perry MJ, Ramos L, Robaire B, Ward S and Zini A. Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications—a position report. Human Reproduction; Apr;25(4):824-38
2010 Castilla JA, Zamora S, Gonzalvo MC, Luna Del Castillo JD, Roldan-Nofuentes JA, Clavero A, Björndahl L, Martínez L. Sperm chromatin structure assay and classical semen parameters: systematic review. Reprod Biomed Online. 2010 Jan;20(1):114-24
2010 Björndahl L and Kvist U. Human sperm chromatin stabilization: a proposed model including zinc bridges, Molecular Human Reproduction, Vol.16, 23–29.
2010 Björndahl L. The usefulness and significance of assessing rapidly progressive spermatozoa. Asian Journal of Andrology; 12: 33–35.
2008 Björndahl L and Haugen TB. Hva forteller saedanalysen? Norsk Legetidskrift, 128(3):320-3.
2006 Björndahl L, Connelly T, Kirkman-Brown J and Barratt CLR. 2006. Reply: Development of a novel home sperm test -temperature range. Human Reproduction, 3028-3029.
2006 Björndahl L, Kirkman-Brown J and Barratt CLR. Reply: Development of a novel home sperm test – What are the limitations? Human Reproduction 3030-3031.
2005 Björndahl L. and Barratt C.L. Semen analysis: setting standards for the measurement of sperm numbers. J Androl; 26(1): 11
2004 Bjorndahl L., Tomlinson M. and Barratt C.L. Raising standards in semen analysis: professional and personal responsibility. J Androl; 25(6): 862-3.
2003 Björndahl & Kvist. Sequence of ejaculation affects the spermatozoon as a carrier and its message. Reprod Biomed Online: 7(4): 440-448.

C] Books and book chapters

2013 Björndahl L. Preconception Gender Selection: Laboratory aspects. In: Intra-Uterine Insemination: Evidence Based Guidelines for Daily Practice. CRC Press, in press.
2013 Björndahl L. Semen Characteristics and aging. In: Paternal Influences on Human Reproductive Success, Cambridge University Press, in press.
2013 Björndahl L & Kvist U. Structure of chromatin in spermatozoa. In: Damage in the genetic material of human spermatozoa: relation to Fertility. Springer Press, in press.
2010 Björndahl, Giwercman, Tournaye, Weidner (eds): Clinical Andrology, Informa Healthcare New York, London, pp 444.
2010 Björndahl, Mortimer, Barratt, Castilla, Menkveld, Kvist, Alvarez, Haugen: A Practical Guide to Basic Laboratory Andrology. Cambridge University Press, Cambridge, pp 348
2010 Björndahl: Basic Semen Analysis and Laboratory Quality for Clinicians In: Clinical Andrology (Björndahl, Giwercman, Tournaye, Weidner (eds): Informa Healthcare, New York, London, p 28-38.
2010 Björndahl: Semen Analysis – Essentials for the Clinician, In: Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice, (Carrell, Peterson, eds), Springer Verlag, 379-388.
2010 Cooper et al (eds.) WHO laboratory manual for the examination and processing of human semen. World Health Organization, Department of Reproductive Health and Research, WHO Geneva, Switzerland, pp 1-287.
2002 Kvist & Björndahl (eds.) Manual on Basic Semen Analysis (NAFA-ESHRE 2002), ESHRE Monograph, Oxford University Press, Oxford.
1998 Björndahl & Kvist, Basic Semen Analysis Courses: experiences in Scandinavia, In Modern ART in the 2000s (eds Ombelet et al), Parthenon Publishing Broup, New York-London, pp 91-102.
1991 Kvist, Björndahl, Kjellberg, Rodriguez-Martinez & Plöen. Importance of zinc for stabilization of sperm chromatin. In Comparative Spermatology 20 years after (ed Baccetti), Raven Press, New York, pp 49-53.

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 - reproduction

SOCIETIES

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